Copy number Alterations¶

MYC was the gene most frequently affected by somatic CNAs (gained in 81% of patient samples), with frequent gains in E2F3 (55%), IRS2 (49%), CCNE1 (47%), EGFR (47%), NFIB (44%), CCND1 (44%), and MYB (41%) and frequent losses in CHD1 (lost in 71% of samples), PTEN (58%), RB1 (54%), and CDKN2A (43%).